5
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T77778 | KP-457 | TNF‐α‐converting enzyme | |
KP-457 (TNF-α-converting enzyme) is a selective inhibitor of ADAM17, with an IC50 value of 11.1 nM/L in cell-free assays. The compound can also cleave a variety of molecules, including GPIbα, GPV and TNF-α. | |||
T69181 | BMS-566394 | ||
BMS-566394 is a potent, exceptionally selective inhibitor of TNF-α converting enzyme (TACE). | |||
T14312 | Apratastat | MMP , TNF | |
Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs) and it also can potently inhibit the release of TNF-α in vitr... | |||
T37726 | MMP-9 Inhibitor I | ||
MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively). It also decreases the activity of TNF-α converting enzyme (TAC... | |||
T83768 | Zofenoprilat | Zofenopril-SH,SQ 26,333 | |
Zofenoprilat, an angiotensin-converting enzyme (ACE; IC50 = 8 nM for rabbit lung enzyme) inhibitor and the active metabolite of the prodrug zofenopril, effectively counters angiotensin I- or bradykinin-induced contractio... |